Most common site of giant cell tumor

Giant Cell Tumor - Pathology - Orthobullet

Giant Cell Tumors are benign, aggressive tumors typically found in the epiphysis of long bones, most commonly at the distal femur and proximal tibia. Patients typically present between ages 30 and 50 with insidious onset of pain of the involved extremity with activity, at night, or at rest Giant cell tumors are usually found in the long bones, most often the distal femur, proximal tibia, and distal radius. Giant cell tumor is a one of the most common primary bone lesions in the distal phalanx Illustration shows a giant cell tumor at the lower end of the thighbone. This is a common location for the tumors to occur. Most often, the tumors occur close to the knee joint—either in the lower end of the thighbone (femur) or the upper end of the shinbone (tibia). Other common locations include the Females are more likely to develop giant cell tumors than males with a 1.3-1.5: 1 ratio. These tumors most frequently involve the epiphyses ends of long bones with the femur, tibia, and distal radius most commonly involved.. Giant cell tumors usually form in bones and are most often found in the knee. They can also develop in leg and arm bones, the breastbone and the pelvis. Giant cell tumors may also be found in the soft tissue surrounding joints, usually forming in the hands and fingers. These tumors are called giant cell tumors of the tendon sheath

Giant Cell Tumor BoneTumor

Giant cell tumors of bone, also known as osteoclastomas, are relatively common bone tumors and are usually benign. They typically arise from the metaphysis of long bones, extend into the epiphysis adjacent to the joint surface, and have a narrow zone of transition a Giant Cell Tumors (GCT) is a benign aggressive tumor typically found in the metaphysis of long bones, often around the knee, in young adults treatment is generally curretage, adjuvant treatment, and reconstruction as necessary depending on location of lesio The most common location for giant cell tumor to arise is distal femur. It is rare to have giant cell tumor arising in thorax (1% of all giant cell tumor cases) and if does it is usually from rib. We report a case of giant cell tumor of pleura who presented with minimal symptoms The term giant cell relates to the appearance of the tumor cells under the microscope. The most common sites are the palm-surfaces of the thumb, index, and middle fingers. The mass is slow-growing, firm, lobulated, and usually painless. These tumors can grow larger if left alone Background: Giant cell tumor of the tendon sheath is the most common form of giant cell tumors and is the second most common soft tissue tumor of the hand region after ganglion cyst. Magnetic resonance imaging is the diagnostic tool of choice for both diagnosis and treatment planning. The current standard treatment of choice is simple excision

Tenosynovial giant cell tumors are benign (not dangerous), slow-growing tumors that affect joints in the fingers, hands, arms, shoulders, or legs. These tumors are relativity common, particularly in the hands and fingers. They are also called giant cell tumors of the tendon sheath or fibrous histiocytoma of the tendon sheath. 1 ď» Giant cells are also less common in the diffuse form. The histologic features of the localized and diffuse forms of giant cell tumor of the tendon sheath and those of the localized and diffuse.

Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass Central giant cell granuloma. Central giant cell granulomas are benign lesions that most often occur in the front portion of the lower jaw. Some of these tumors can grow rapidly, can cause pain and destroy bone, and have a tendency to recur after surgical treatment. The other types are less aggressive and may not have symptoms 3. DEFINITION • Distinct neoplasm arising from non-bone forming supportive connective tissue of marrow with network of stromal cells regularly interspersed with giant cells • Tumor is called GCT because Giant cells are found • These Giant cells resemble osteoclasts..hence called as OSTEOCLASTOMA. 4 Giant-cell tumor of the bone (GCTOB), is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells (osteoclast -like cells). Malignancy in giant-cell tumor is uncommon and occurs in about 2% of all cases. However, if malignant degeneration does occur, it is likely to metastasize to the lungs Giant cell tumors of the tendon sheath are the second most common tumors of the hand, with simple ganglion cysts being the most common. Chassaignac first described these benign soft-tissue masses in 1852, and he overstated their biologic potential in referring to them as cancers of the tendon sheath

Giant cell tumor of the tendon sheath (GCTTS), tenosynovial giant cell tumor (TGCT), and pigmented villo-nodular synovitis (PVNS) are the common names for a group of rare proliferative disorders that involve synovial joints and tendon sheaths. Considerable confusion exists about the surgical treatment and diagnosis of these disorders Giant cell tumor of bone mostly occurs at the ends of the long bones of the arms and legs, often close to the knee joint (5). These tumors, which typically occur in young and middle-aged adults, can be locally aggressive, causing destruction of bone. In rare cases they can spread (metastasize), often to the lungs

Soft tissue at Weill Cornell Medical College - StudyBlue

Giant Cell Tumor of Bone - OrthoInfo - AAO

Serious adverse events were reported in 138 (26%) of 526 patients; the most common were osteonecrosis of the jaw (17 [3%]), anaemia (6 [1%]), bone giant cell tumour (6 [1%]), and back pain (5 [1%]). 28 (5%) patients had positively adjudicated osteonecrosis of the jaw, four (1%) had atypical femur fracture, and four (1%) had hypercalcaemia occurring 30 days after denosumab discontinuation Giant cell tumor (GCT) of bone often arises from the long bones. Although the spine is the fourth leading location of GCT, the majority of these lesions occur in the sacrum .In several large series, only 1% to 2 % of GCTs occurred in the thoracic spine .GCTs of the spine sometimes extend into the paraspinal soft tissue , but a primary thoracic spinal GCT simulating a huge mediastinal neoplasm. Giant cell tumour, also known as osteoclastoma, is a fairly common bone tumour accounting for 5% of all the primary bone tumours. It is a benign tumour with a tendency for local aggressiveness and high chances of recurrence. The most common sites are distal end of femur, upper end of tibia and lower end of radius [ 1 ] Giant cell tumor of bone is a rare, fast-growing noncancer tumor. It most often grows in adults between ages 20 and 40 when skeletal bone growth is done. It is slightly more common in women. It often grows near a joint at the end of the bone. The location of a giant cell tumor is often in the knee, but can also grow in the bones of the arms and. Giant cell tumor of bone is a rare, fast-growing noncancer tumor. It often grows near a joint at the end of a bone. Read on to learn about symptoms, diagnosis, and treatment

Giant Cell Tumor - Physiopedi

  1. Solitary fibrous tumors (SFT) are rare spindle cell neoplasms that were first described by Klemperer and Coleman1 as mesenchymal tumors that arise in the pleura. Although the most common site of SFTs is the intrathoracic region, they can also occur at various extrathoracic sites, including the liver, nasal cavity, orbit, thyroid, meninges, skin, kidney, and other organs.2-4 Since Dei Tos et al.
  2. Some cases show a paucity of giant cells, which is why it is best to know the constellation of histologic features aside from the presence of giant cells in order to make the diagnosis in giant cell poor cases. Tenosynovial giant cell tumor, localized type, is the second most common tumor of the hand (ganglion cyst is most common)
  3. Giant cell tumors also metastasize without undergoing malignant transformation in 1% to 6% of cases. 19,20,26,43,47,55 The lung is the most common site of benign metastasis, 47 although spread also occurs to long bones, 11,44,53 spine, 16,55,60,62 pelvis, 10,13,42,52 ribs, 57 brain, 51 lymph nodes, 8,34,35,46 soft tissue, 22,47 and viscera. 15,2
  4. Giant-cell tumor of bone. - Discussion: - a common benign but locally aggressive lesion of unknown etiology; - occurs chiefly in men between 20-50 yrs (after epiphyseal closure); - tumor is expansile lytic lesion that involves the epiphysis & metaphysis; - tumor may enlarge to occupy most of epiphysis & adjacent metaphysis; - tumor may erode.
  5. Giant Cell Tumors Giant cell tumors are benign growths that form on top of the foot, on the toes, or on the sole of the foot. Giant cell tumors are painful to the touch and can interfere with the tendons in the feet which can cause pain and difficulty in walking. Giant cell tumors are commonly removed through surgery

Pain and neurologic deficits are the most common presenting symptoms. A giant cell tumor is composed of osteoclastic giant cells within a spindle cell stroma. Hemorrhagic and fibrotic areas are commonly found. Spontaneous malignant transformation was reported in fewer than 2% of patients , but it often occurs after radiation therapy. Giant cell. Tenosynovial giant cell tumors are benign, growing on joints in the hands, arms, or legs. They are the second most common tumors of the hand. They are also called giant cell tumors of the tendon sheath or fibrous histiocytoma of tendon sheath. PVNS is also called diffuse-type giant cell tumor. PVNS is more likely to affect an entire joint and.

Giant Cell Tumor of Bone and Soft Tissue - St

Giant cell tumors of tendon sheath are usually small nodules between 0.5 and 3 cm in size. The uncommon localized intraarticular examples within the ankle, elbow, or hip may be larger. On gross examination, giant cell tumor of tendon sheath is a well-circumscribed, lobulated mass with a white, fibrous cut surface Iatrogenic seeding may represent a cause of multicentric giant cell tumors . The most common site of the primary GCT is around the knee (44%), followed by wrist (23%) and hand and feet (13%), and is consistent with localization of solitary GCT. Diaphyseal involvement is more found in multifocal than in solitary GCT Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE

What is the most common site of osteoid osteomas? The proximal femur. What are the symptoms of a benign giant cell tumor? Pain and limited motion at the adjacent joint, a visible mass, swelling, fractures, and fluid accumulation in the joint Continued. ‌Tenosynovial giant cell tumors are caused by a translocation of certain parts of chromosomes 1 and 2. This causes the cells to overproduce a protein called colony-stimulating factor. Giant cell tumor of tendon sheath is the most common form of TSGCT. As the name implies, it arises from synovial-lined tendon sheaths. Giant cell tumor of tendon sheath occurs at any age, with peak incidence in the third to fourth decades. It usually presents as a painless, slowly growing mass

Giant cell tumor of bone Radiology Reference Article

most common site for chondrosarcoma. lower extremity, pelvic bones. required to make dx of chondrosarcoma. xray: MUST see destructive pattern with extension to soft tissue Giant cell tumor of bone definition. bening tumor of multinucleated giant cells (osteoclasts) in. demographic of giant cell tumor. adults. location of giant cell turmo. Background. Giant cell tumour (GCT) of bones is one of the most common benign bone tumours and usually involves the metaphysis-epiphysis region of long bones, especially the distal femur, although occurrences in other regions have been reported.1 The hand is one of the rarest sites for bone GCT, but it has a high recurrence rate and can easily be misdiagnosed.2 3 Careful examination, complete. Giant cell arteritis causes inflammation of certain arteries, especially those near the temples. The most common symptoms of giant cell arteritis are head pain and tenderness — often severe — that usually affects both temples. Head pain can progressively worsen, come and go, or subside temporarily. Pain and stiffness in the neck, shoulders. Common physical examination findings of giant cell tumor are localized swelling and tenderness at the site of the tumor. Giant cell tumor of bone must be differentiated from aneurysmal bone cyst, chondroblastoma, simple bone cyst, osteoblastoma,giant cell rich osteosarcoma, and brown tumor of hyperparathyroidism. X-ray may be helpful in the.

Most common sites: Lung, mesentery, omentum. Any age, but more common in children. Bland spindled to stellate cells in myxoid to hyalinize stroma. Can have loose, fascicular, or storiform growth. Prominent lymphoplasmacytic infiltrate. Most cells bland, but sometimes large cells with prominent nucleoli. IHC: Variable staining with actin/desmin Giant cell tumors (GCTs) are a rare etiology of head and neck tumors. These benign neoplasms mainly affect the long bones. A trend toward local recurrence and late malignant change with distant metastases, especially to the lung, has been reported (1, 2).Complete surgical resection is the gold standard treatment but may lead to significant functional deficits in this particular localization

Introduction. Giant cell tumor (GCT) of bone was first described by Sir Astley Cooper in 1818 (, 1).Historically, the lesion has been referred to by numerous terms, including myeloid sarcoma, tumor of myeloplaxus, osteoblastoclastoma, and osteoclastoma (, 2-, 5).. GCT is a relatively common skeletal tumor, accounting for 4%-9.5% of all primary osseous neoplasms and 18%-23% of benign bone. Symptoms of a Giant Cell Tumor of Bone. Not everyone will experience symptoms of a giant cell tumor in the same way. Many of the most common symptoms of a giant cell tumor of bone also resemble other medical conditions that are routine. You should always consult your doctor if you experience worrisome symptoms that won't go away They are most common in or just under the skin and there might be more than one tumor. Rhabdomyosarcoma is the most common type of soft tissue sarcoma seen in children. See Rhabdomyosarcoma. Synovial sarcoma is a malignant tumor of the tissue around joints. The most common locations are the hip, knee, ankle, and shoulder

giant cell tumor of bone). IHC: (+) S100, DOG1 Chondromyxoid fibroma Benign. Occurs in many sites, but often long bones near the knee. Lobulated lesion with sharp margins and zonal architecture. Chondroid and stellate cells embedded in a chondroid to myxoid matrix in the center of each lobule. Peripheral spindled cells and admixed giant cells tumor, the lesions were composed essentially of variable proportions of round or polygonal cells, multinucleated giant cells, siderophages, and foam cells. There was an intermingling of fibrous collagenous tissue, which was of- ten hyalinized. The characteristic lobulation was con- firmed microscopically (Fig. 5)

Giant Cell Tumor of Talus: A case report of late

Giant cell tumors of the bone are not uncommon and account for 20% of primary bone lesions found in patients in China. 22 The distal radius is the third most common site for lesions next to the distal femur and the proximal tibia. The goals of treatment are to remove the tumor, lessen the chance of local recurrence, and preserve function of the joint Primary malignancy in giant cell tumor of bone (PMGCT) is extremely unusual. Eight cases were reported by Nascimento et al. 1 and five by the Mayo Clinic. 2 Cases also have been described by others on occasion. 3-7 Secondary malignancy in giant cell tumor of bone (SMGCT) is more common and can occur after radiotherapy and/or surgery. 2-4, 8-21 We reviewed cases of malignancy in giant cell. There are a few common types of benign bone tumors: Osteochondroma is the most common. It often happens in people under age 20. Giant cell tumor is usually in your leg. In rare cases, these can. Synovial sarcoma is a common soft tissue malignancy accounting for 5 - 10 % of soft tissue sarcomas. Patients with synovial cell sarcoma are often between the ages of 15 and 35 years old; generally younger than patients with other types of soft tissue sarcomas. The most probable cellular origin is an undifferentiated mesenchymal cell Giant cell tumors. Giant cell tumors grow aggressively. They occur in adults. They're found in the rounded end of the bone and not in the growth plate. The most common sites for this tumor.

A massive intrathoracic mass lesion due to giant cell

Mast Cell Tumors. Mast Cell Tumors are the most common skin tumors in dogs. Mast cell tumors can look and feel like anything, so it is impossible to diagnose without looking at cells under the microscope. After close examination, a grade of malignancy is assigned. The grade suggests how the tumor will behave and the best course of treatment Squamous cell carcinomas are thought to arise in the epidermis or from regions in the outer root sheath of the hair follicle. Although most arise without known cause, prolonged exposure to sunlight is believed to be a major predisposing factor. Squamous cell carcinomas are the most common malignant skin tumor in horses This is the most common of the mixed neuronal-glial tumors and generally appears in childhood or the early teen years. The majority are benign and can usually be treated successfully by surgery. Subependymal giant cell tumor. These tumors are common in children who have a genetic condition called tuberous sclerosis. These tumors are rarely. giant cell tumor: [ too´mor ] 1. swelling or morbid enlargement; this is one of the cardinal signs of inflammation . 2. a new growth of tissue in which cell multiplication is uncontrolled and progressive. Tumors are also called neoplasms , which means that they are composed of new and actively growing tissue. Their growth is faster than that. A mast cell tumor (MCT) is a type of tumor consisting of mast cells. Mast cell tumors most commonly form nodules or masses in the skin, they can also affect other areas of the body, including the spleen, liver, intestine, and bone marrow. MCTs are particularly common in Boxers, Bull Terriers, Boston Terriers, and Labrador Retrievers. This cancer is typically diagnosed via fine needle aspiration

lumps and bumps and cysts of the hand - John Erickson, M

The most common serious adverse reaction was pneumonia. The most common adverse reaction resulting in discontinuation of XGEVA ® was osteonecrosis of the jaw. The most common adverse reactions in patients receiving XGEVA ® for giant cell tumor of bone were arthralgia, headache, nausea, back pain, fatigue, and pain in extremity. The most. Giant cell tumor of the tendon sheath is the most common form of giant cell tumors and is the second most common soft tissue tumor of the hand region after ganglion cyst. Magnetic resonance imaging is the diagnostic tool of choice for both diagnosis and treatment planning. The current standard treatment of choice is simple excision. The main concern about the treatment is related to the high. Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date

Giant Cell Tumor Patient (Aggressive) | Charity

Giant cell tumor of tendon sheath in the hand: analysis of

Giant Cell Tumor of Bone accounts for 4-8% of primary bone tumors. It is most commonly seen in women aged 20 to 40 years. The most common sites are the distal femur and proximal tibia, distal radius, and proximal humerus. Increasing pain at the tumor site is the most common presenting symptom Giant cell tumors of the tendon sheath - develops in connective tissue, commonly near the knee joint; Undifferentiated Pleomorphic sarcoma - most common in the lungs in adults over the age of 50 (but can develop anywhere in the body) Plexiform Fibrohistiocytic tumor - usually affects the skin of the upper limb Tenosynovial giant cell tumor (TGCT), also known as pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS), is a group of rare tumors that typically arises from the synovium of joints, bursae, and tendon sheaths. 1-3 They are typically non-malignant neoplasms but can be locally aggressive. 1,4 TGCT encompasses 2 broad subtypes—diffuse and localized—that. Giant cell tumor (GCT) of bone is one of the most common benign bone tumors accounting for 22% of benign bone tumors and 4-7% of all primary bone tumors [1, 2]. GCT is a benign but locally aggressive tumor and may even metastasize to the lungs. Rarely it presents as a malignant GCT Bones in the legs, arms, and jaw are most often affected. Giant cell tumor of bone. This type of primary bone tumor can be either benign (not cancer) or malignant. The benign form is more common. These tumors are most common in people in their 20s and 30s. Giant cell bone tumors typically affect the legs (usually near the knees) or arms

An Overview of Tenosynovial Giant Cell Tumor

Tenosynovial giant cell tumor (TGCT) is a group of rare tumors that form in the joints. It's not cancer. Continue reading to learn more about TGCT, its causes, treatments, and more Tumor tissue reveals many rounded synovial-like cells with a good amount of giant cells and inflammatory cells. Treatment involves an excision of the tumor. If the PVNS is widespread, a complete synovectomy (excision of the membrane that lines joints lubricating them with fluid) must be done Central giant cell granulomas are non-neoplastic lesions of unknown etiology. They affect females more than males with the mandibular anterior region being the most common site of occurrence

Giant cell tumor of tendon sheath (GCTTS) is a firm, nontender, slow growing, benign soft tissue neoplasm. It is the second most common tumor of the hand after ganglion.[1,2]. These round cell tumors are the most common type of bone cancer in adults. Patients are usually older, between the ages of 50 and 80. These tumors usually respond well to chemotherapy and radiation. Lymphoma. These round cell tumors are most likely of the non-Hodgkin's type and are often found in multiple areas of the body Germ cell tumors are rare. Germ cell tumors account for about 2 to 4 percent of all cancers in children and adolescents younger than age 20. Germ cell tumors can spread (metastasize) to other parts of the body. The most common sites for metastasis are the lungs, liver, lymph nodes, and central nervous system Giant cell tumor of bone is a relatively common tumor in skeletally mature patients that typically involves the epiphysis of the long bones, often involving the subarticular site [1, 2].It is.

Which microscopic histologic findings characteristic of

Introduction. Giant cell tumor of tendon sheath (GCTTS) and ganglion cyst are the most common benign tumors of the hand (1, 2).In general GCTTS can present as a solitary subcutaneous nodule of the hand, but it can also occur in other parts of the body such as the spine, ankle, knee and feet (3, 4).However, with an approximate incidence of 1/50,000 per population it remains an uncommon. Ultrasound features favored a possibility tenosynovial giant cell tumor. Surgical excision of the lesion was done and histopathology confirmed the lesion being tenosynovial giant cell tumor. It is the most common soft-tissue lesion of the hand and wrist 1. Intraoperative and gross pathology photos courtesy: Operating surgeon Dr. Nisarg A. Patel Giant cell tumor of tendon sheath is the most common form of TSGCT. Tenosynovial giant cell tumor: case report and review INTRODUCTION: Giant cell tumor of tendon sheath (GCTTS) is clinically a slow growing soft tissue mass that develops over a period of months to years calcifying giant cell tumor or chondromatous giant cell tumor. It occurs in elder children and young adults, rarely over the age of 20 years. The usual sites are the femoral and tibia1 epiphyses around the knee-joint, and the upper humeral epiphysis. The symptoms are insidious, wit The most common site of presentation is the mandible and the maxilla followed by bones of the hands and feet.3,4 GCRG rarely occurs in the nasal cavity, paranasal sinuses, or the orbit. giant cell tumor (GCT), both present similar clinical and histological features. 6 Clinically, GCT is common in th

A Solitary Fibrous Tumor with Giant Cells in the Lacrimal

Risk factors for local recurrence were pathologic fracture, stage III disease, anatomic site, and the use of adjuvant treatment. The distal radius and the proximal tibia had the highest rate of local recurrence. O'Donnell RJ, Springfield DS, Motwani. HK, et al. Recurrence of giant-cell . tumors. of the long bones after curettage and packing. GCTBs are benign bone tumors consisting of two cellular components: interstitial tumor cells and a large number of multinuclear giant cells. These tumors most frequently de-velop in individuals of 20 to 39 years of age. Common tumor sites are the distal femur and proximal tibia. Local recurrence rates range from 10 to 25 %. The interval unti A giant cell tumor of tendon sheath (GCTTS) is a soft tissue tumor consisting principally of a proliferation of synovial cells arising from a tendon sheath. GCTTS is the second most common tumor of the hand in general and a majority of GCTTS cases are in patients between 20 and 50 years of age, whereas pediatric cases of GCTTS are uncommon Osteosarcoma is a form of cancer. It is a type of tumor that affects the bones. Osteosarcoma can affect people at any age, but is most common during the teen-aged years, and is the most common bone cancer affecting children and adolescents under the age of 20. The long bones of the legs, usually near where they connect to the knees, and the.

Jaw tumors and cysts - Symptoms and causes - Mayo Clini

Giant cell tumor is an osteolytic, generally benign neoplasm, accounts for 5% of primary skeletal tumors[5]. According to SEER(National Cancer Institute's Surveillance, Epidemiology and End Results) database, the estimated annual incidence of GCT in the United States was 1.6 per 10,000,000 persons per year with a highest incident age of 20 to 45 years old[6,7] Background Aneurysmal bone cyst (ABC) secondary to Giant Cell Tumor of bone (GCT) is a rare lesion, of which the incidence is about 0.011 to 0.053 per 100,000 every year. There are only a few previous case reports, and most of them occur in the spine, long bones or flat bones. Case presentation We report one case of a patient who complained of progressive enlargement of the mass on right.

Giant Cell Tumor of Tendon Sheath | Basicmedical KeyPATHOLOGY at Brown University - StudyBlueShareMyRadiology 放射线学: Phyllode tumour of the breastFeline Injection Site SarcomaExam 3 - Musculoskeletal Tumors Flashcards | Quizlet

Juvenile xanthogranuloma (JXG) is a rare, benign proliferative non-Langerhans cell histiocytic proliferation. Occurs predominantly in young children. Clinically, it presents as a solitary red-brown, yellowish papule or nodule, most often on the head and neck area. Systemic JXG is rare and may involve any organ system Giant cell tumor of the tendon sheath (GCTTS) is a benign nodular tumor that has become increasingly frequent in the foot and ankle. 1-3 This tumor especially affects the small joints in the extremities and usually presents as a solitary soft-tissue mass; however, simultaneous multi-fragmented lesions in the foot have been reported as an uncommon presentation. 4,5 It can be seen at any age but. Osteoblastoma and giant cell tumor of bone may become malignant after starting as benign. They will usually become aggressive without spreading to distant sites and cause damage to the bone near the tumor. Pain in the area of the tumor is the most common sign of bone cancer. At first, the pain might not be there all the time. It may get. all the primary bone tumors. Giant-cell tumor is not a tumor of the giant-cells. Giant-cell is reactive, the hence more the number of such cells, the better is the prognosis. The nature of the neoplastic stromal cell remains controversial. It is clearly mesenchymal rather than hemopoetic in nature. The ultra-structural feature Tenosynovial Giant Cell Tumor Fibroma of Tendon Sheath; Oval histiocyte-like nuclei : Elongate nuclei : Giant cells nearly always present: Giant cells rare: Foamy histiocytes common: Histiocytes rare: Hemosiderin common: Hemosiderin rare: No slit-like vascular spaces: Slit-like vascular spaces common: Smooth muscle actin negative: Smooth muscle.